Isotretinoin is a powerful drug that should only be used for acne blemish treatment in extreme circumstances. While it is available in different dosage levels and side effects tend to be less severe at
lower doses, the use of isotretinoin for acne is monitored very closely due to the potential health risks involved. As of 2006, the FDA requires dermatologists, pharmacists, and patients to register and visit the iPLEDGE website dedicated to the careful dispensing and use of isotretinoin.
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